起始不同基础胰岛素治疗HbA1c的改善情况T2DM患者基础胰岛素+OAD治疗模式RCT9.5 9.0 HbA1c (%) 8.5 8.0 7.5 7.0 6.5YkiJarvinen 2000 Massi Benedetti 2003 Riddle 2003Eliaschewitz Hermansen Philis2006 2006 Tsimikas 2006 Rosenstock 2008 Blonde 2009 Hollander Dornhorst 2007 2011
OB§§ §
地特胰岛素 NPH 甘精胰岛素 磺脲类
#
控制 目标
predictive
Solve 2011
A1chieve 2011
FPG 目标 3.9-5.0mmo/L; FPG 目标4.4-6.1mmol/L; § 早上注射地特胰岛素; §§ 晚上注射地特胰岛素；#与Sitagliptin联用 Adapted from Devries et al. Diabetes Metab Res Rev 2007; 23:441-54. Hollander et al. Diabetes Obes Metab 2011;13:268–75 Philip Home, et al. Diabetes Res Clin Pract 2011; 94:352-363.