Author manuscript, published in "Statistics in Medicine 2009;28(14):1940-56"
DOI : 10.1002/sim.3573
Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization
using a pharmacokinetic/pharmacodynamic model
Caroline Bazzoli*, Sylvie Retout, France Mentré
INSERM, U738, Paris, France; Université Paris Diderot, UFR de Médecine, Paris, France
*
corresponding author: Caroline Bazzoli,
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002Inserm U738, raM16, rue Henri Huchard 72 - 75018 Paris, France 1 noiFax: 33 1 44 85 62 83
sre v,Email: caroline.bazzoli@inserm.fr
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