向四环素为淡黄色。因其不稳定又易变成黑色，脱色四环素为橙红色，差向脱水四环素为砖红色。此类杂质的存在均可以使四环素的外观色泽变深。因此中国药典和BP（2005）均规定了一定溶剂，一定浓度，一定波长下杂质吸收的限量。方法如下：
取本品，在20-25°C时加0.8%氢氧化钠溶液制成每1ML中含10MG的溶液，照紫外-可见分光光度法，置4CM的吸收池中，在530NM的波长处测定，自加0.8%氢氧化钠溶液起5分钟时，其吸光度不得低于0.12.
满分：10 分
2. 《中国药典》(2010年版)中所指的重金属是什么？检查重金属是以什么为代表？为什么？
重金属是指在实验条件下（pH≤3.5）能与硫离子作用（反应）显色（生成硫化物沉淀）的金属杂质。如银，铅，汞，铜，镉，铋，砷，锌，钴，镍等；检查重金属以铅为代表；因为自然界中铅分布较广，在药物生产过程中接触铅的机会也比较多，铅在人体内容易引起积蓄中毒；
满分：10 分
3. 甾体激素类药物可分为哪几类？
甾体激素类药物按药理作用分为肾上腺皮质激素和性激素两大类；性激素又分为雄性激素及蛋白质同化激素，孕激素和雌激素；肾上腺皮质激素（简称皮质激素）临床上有醋酸可的松，氢化可的松，醋酸地塞米松，地塞米松磷酸钠等；
满分：10 分
4. 三点校正紫外分光光度法测定维生素A含量的依据(原理)是什么? 1.物质对光的吸收具有加成性；2.杂质的无关吸收在310-340nm范围内几乎呈一条直线，且随波长的增大吸收度下降；
满分：10 分
5. 什么是杂质和杂质限量？杂质限量通常用什么表示?
杂质是指药物中存在的无治疗作用，或影响药物的稳定性和疗效，甚至对人体健康有害的物质；杂质限量即为药品中所含杂志的最大限量；杂质限量通常用百分之几或万分之几表示；
满分：10 分 6. 何谓硫色素反应?
答：维生素B1在碱性溶液中，可被铁氰化钾氧化生成硫色素。硫色素溶于正丁醇中，显蓝色萤光。方法：取本品5MG加氢氧化钠试液2.5ML溶解后，加铁氰化钾试液0.5ML与正丁醇5ML，强力振摇2分钟，放置使分层，上层显强烈的蓝色萤光， 加酸使呈酸性，萤光即消失，再加碱使呈碱性，萤光又重现。硫色素反
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应为维生素B1所特有的专属反应，用作为本品的鉴别。 满分：10 分
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（英文版 ）
Two regulations promulgated for implementation is in the party in power for a long time and the rule of law conditions, the implementation of comprehensive strictly strategic plan, implementation in accordance with the rules and discipline to manage the party, strengthen inner-party supervision of major initiatives. The two regulations supporting each other, the < code > adhere to a positive advocate, focusing on morality is of Party members and Party leading cadres can see, enough to get a high standard; < rule > around the party discipline, disciplinary ruler requirements, listed as \focusing on vertical gauge, draw the party organizations and Party members do not touch the\from four square face two party rules of interpretation: the first part introduces two party Revised regulations the necessity and the revision process; the second part is the interpretation of the two fundamental principles of the revision of laws and regulations in the party; the third part introduces two party regulations modified the main changes and needs to grasp several key problems; the fourth part on how to grasp the implementation of the two regulations of the party. < code > and < Regulations > revised the necessity and revised
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history of the CPC Central Committee the amendment to the Chinese Communist Party members and leading cadres honest politics several guidelines > and < Chinese Communist Party discipline and Punishment Regulations > column 1 by 2015 to strengthen party laws and regulations focus. Two party regulations revision work lasted a Years, pooling the wisdom of the whole party, ideological consensus, draw historical experience, respect for the wisdom of our predecessors, which reflects the unity of inheritance and innovation; follow the correct direction, grasp the limited goals, adhere to the party's leadership, to solve the masses of the people reflect a focus on the problem. The new revision of the < code > and < rule >, reflects the party's 18 and the eighth session of the third, the spirit of the fourth plenary session, reflecting the experience of studying and implementing the General Secretary Xi Jinping series of important speech, reflects the party's eighteen years comprehensive strictly practice. (a) revised two regulations of the party need of < the ICAC guidelines > in < in 1997 Leaders as members of the Communist Party of China clean politics certain criteria (Trial) > based on revised, the promulgation and implementation of January 2010, to strengthen the construction of the contingent of leading cadres play an
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important role. But with the party to manage the party strictly administering the deepening, has not been able to fully meet the actual needs. Content is too complicated, \prohibition, 52 are not allowed to\hard to remember, and also difficult to put into practice; the second is concisely positive advocated by the lack of prohibited provisions excessive, no autonomy requirements; the third is banned terms and discipline law, both with the party discipline, disciplinary regulations repeat and Criminal law and other laws and regulations repeat; the fourth is to \not prominent, not for the existing problems, and is narrow, only needle of county-level leading cadres above. < rule > is in 1997 < Chinese Communist Party disciplinary cases (Trial) > based on revision, in December 2003 the promulgation and implementation, to strengthen the construction of the party play very important role. Along with the development of the situation, which many provisions have been unable to fully meet the comprehensive strictly administering the practice needs. One is Ji law, more than half of the provisions and criminal law and other countries laws and regulations Repetition; two is the political discipline regulations is not prominent, not specific, for violation of the party constitution, damage the
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