苏州大学《免疫学》H卷
考试形式 闭卷
院系 ___________ 年级 ____________ 专业 ____________ 学号 ___________ 姓名 ____________ 成绩 ____________
A. Multiple choice questions (2? × 25 )
1.Which cytokine can promote T cell proliferation and differentiation A.IL-1 B.IL-2 C.IL-3 D.G-CSF E.TGF-β
2. Which one of the following can directly and specifically kill target cells A. TH cells B. Tc cells C.NK cells D. Macrophages E. neutrophils 3. Blood transfusion reactions caused by mis-mathched blood transfusion belongs to A.type I hypersensitive reaction B.type II hypersensitive reaction C.type III hypersensitive reaction D.type IV hypersensitive reaction 4. Which kind of cytokine contributes to B cell antibody class switching to IgE A.IL-1 B.IL-2 C.TGF-β D. IL-4 E.IL-5
5. Auto-reactive lymphocyte clones are mainly deleted in
A.Thymus B.Bone Marrow C.Spleen D.Bone marrow and Thymus
6. Phagocytosis
A. is carried by cells of the adaptive immune system B. is restricted to macrophages C. is important in bacterial infections D. is a process that does not involve energy E. results in division of the cell
???Dendritic cells are characterized by A. the presence of major basic proteins B. expression of CD3
C. expression of IgM molecules D. their ability to release histamine
E. their interface between the innate and adaptive immune systems
8 Activation of the alternative pathway involves A. C1 B. C2 C. C3 D. C4
9. B cells are distinguished from T cells by the presence of
A. CD3 B. CD4 C. CD8 D. surface Ig E. class I MHC antigen
10. Allotypes are
A. antigenic determinants which segregate within a species B. critical to the function of the antibody combining site C. involved in specificity D. involved in memory
11. The Fab portion of Ig
A. binds to a Fc receptor B. contains the J chain C. contains the idiotype of the Ig
D. mediates biological effector functions of Ab molecules (e.g. complement activation)
12. Antibody dependent cell mediated cytotoxicity (ADCC) A. is carried out by B cells
B. is the main mechanism for killing intracellular microbes C. involves Fc receptors on the effector cells D. is primarily mediated by IgE antibody
13. Viral replication within cells is inhibited by
A. IL-13 B. IL-1 C. IFN-??????????D. TNF-????????E. IL-4
14. Cytotoxic T cells generally recognize antigen in association with A. Class I MHC determinants B. Class II MHC determinants C. Class III MHC determinants D. HLA-DR determinants
15. All of the following are true about receptors of the innate immune system, EXCEPT that they A. include those of the Toll family
B. recognize molecular patterns associated with groups of microbes C. include CD14 and scavenger receptors D. include MHC molecules E. do not include Ig? and Ig???
16. All of the following are true about class switching of antibodies EXCEPT that A. particular Th subsets are required
B. it occurs in germinal centers o lymph nodes C. cytokines are required
D. it occurs in patients with Di George syndrome
E. it does not occur in patients with a genetic defect in CD40L
17. CTL
A. do not mediate cytotoxicity of other T cells infected with virus
B. mediate killing by insertion of perforin into the membrane of the target cell C. do not need to recognized MHC antigens on the target cell to kill D. recognize antigens with MHC II molecules E. normally help B cells to make antibodies
18. Super-antigens
A. activate large numbers of T cells by directly binding to the TCR? chain and class II MHC
B. are high molecular weight antigens that can trigger T cell proliferation in the absence of antigen-presenting cells
C. can activate all B cells by binding to IgM D. can only trigger CD8+ T cells
19. The stage in B-cell development at which tolerance can be most easily induced is A. memory B B. pre-B C. immature B D. plasma cell E. mature B
20. The process involved in allowing T cells to survive in the thymus is A. positive selection B. negative selection
C. apoptosis D. necrosis E. complement inactivation
21. Tumor immune surveillance may be mediated by
A. mast cells B. neutrophils C. Langerhans cells D. NK cells
22. Immediate hypersensitivity usually involves
A. mast cells B. antibodies to mast cells C. platelets D. IgG
23. The predominant antigen presenting cell in contact hypersensitivity (e.g. poison ivy) is the
A. T lymphocyte B. B lymphocyte C. basophil D. Langerhans cell E. NK cell
24. Delayed hypersensitivity as typified by the Mantoux reaction to tuberculin is mediated by
A. lymphocytes B. polymorphonuclear cells C. anaphylactic antibodies D. complement binding antibodies E. antigen-antibody complexes
25. ELISA assay
A. results in cell lysis B. uses a radiolabeled second antibody C. involves addition of substrate which is converted to a colored end-product D. requires sensitized red blood cells
B. Explain terms (6?× 5)
1. Adaptive immunity 2.Complement: 3.TCR 4.MHC
5.oncofetal antigens
C. Big questions (10?× 2 )
1. Please describe the structure and functions of antibody.
2. 2-signal theory for T cell activation.