开关，这限制了其临床运用的发展。另一方面，人们对缺氧条件下血脑屏障通透性改变中PI3-K/AKT发挥作用的机制依然缺乏认识。随着蛋白质组学技术和磷蛋白质识别技术的进步，有关PI3-K/AKT及其信号调节分子、下游信号通路及在血脑屏障通透性改变中扮演的作用将可能成为未来研究的方向。
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