维生素B1工艺设计
摘 要
硫胺素（维生素B1）是已经确定的第一个B族维生素。硫胺素依赖酶作为一个与能量代谢有关的几种酶的辅助因子,它是重要的神经递质的合成和生产，减少氧化应激防御中使用的物质，以及用于合成的戊糖核酸的前体.硫胺素脑代谢中起着核心作用。干脚气病，周围神经病变，湿脚气，水肿和乳酸性酸中毒的心肌病，和Wernicke–Korsakoff综合征，其表现包括眼球震颤，眼肌麻痹，共济失调演变成混乱，逆行性遗忘，认知障碍，虚构其不足的结果。严格硫胺素缺乏饮食的患者18天之内显示的严重枯竭的状态。硫胺素缺乏在富裕国家中最常见的原因是不含酒精的病人要么酗酒或营养不良。硫胺素补充治疗是有益的诊断和治疗的。
关键词：硫胺素 维生素B1 脚气 Wernicke-Korsakoff综合征 心肌病 神经病
Abstract
Thiamine (vitamin B1) was the first B vitamin to have been identified. It serves as a cofactor for several enzymes involved in energy metabolism. The thiamine-dependent enzymes are important for the biosynthesis of neurotransmitters and for the production of reducing substances used in oxidant stress defenses, as well as for the synthesis of pentoses used as nucleic acid precursors.Thiamine plays a central role in cerebral metabolism. Its deficiency results in dry beriberi, a peripheral neuropathy, wet beriberi, a car-diomyopathy with edema and lactic acidosis, and Wernicke–Korsakoff syndrome, whose manifestations consist of nystagmus,ophthalmoplegia, and ataxia evolving into confusion, retrograd e amnesia, cognitive impairment, and confabulation. Patients on a strict thiamine-deficient diet display a state of severe deplet ion within 18 days. The most common cause of thiamine deficiency in affluent countries is either alcoholism or malnutrition in nonalcoholic patients. Treatment by thiamine supplementation is beneficial for diagnostic and therapeutic purposes.
Keywords: Thiamine; vitamin B1; beriberi; Wernicke-Korsakoff syndrome; neuropathy;
cardiomyopathy.