MEMBERSHIP OF ACADEMIC ASSOCIATION: Member of American Society of Nephrology (ASN); Member of International Society of Nephrology (ISN); Member of American Physiological Society (APS) Member of Chinese Society of Physiology (CSP) Member of American Diabetes Association (ADA)
Member of American Association for the Advancement of Science (AAAS)
AWARD AND HONOR POSITION:
National Guang Hua Price, 1993, Beijing Medical University
Guest Associate Professor, 1998,05-2001,05, Department of Physiology, Beijing University Medical Center (Beijing Medical University), Beijing100081;
Guest Professor, 2002, 1- present, Division of Nephrology, The General Hospital of PLA, Beijing 100021
ACADEMIC POSITION: Co-Chair, the Symposium “Novel Renal Pathways for Prevention of Diabetes and Obesity-Related Renal and Vascular Disease”. The 2005 Annual Meeting of the ASN, Nov 8-13, Philadelphia, Pennsylvania.
Chairman, the Eicosanoid Receptors Symposium, the International Eicosanoids Conference, Beijing, July 05, 2005
Reviewer, Study Section of Physiology, Pathophysiology and Internal Medicine, National Nature Science Foundation of China (NNSFC), 2004-2008
Reviewer, Study Section of Immunology, National Nature Science Foundation of China (NNSFC), 2005;
Review Committee member, NIDDK RFA-DK-04-012, Study Section of “PKD Research and Translation Core Centers”;
Review Committee member, NIDDK RFA-DK-05-001, Study Section of “Preventing Mitochondrial Oxidative Stress in Diabetes and Obesity”;
Chairman, The Cross-Section Symposium “\2003 FASEB meeting, April 11-14, San Diego.
Chair, The first Diabetes Symposium at Beijing University Medical Center, December 20, 2003;
INVITED REVIEWS: 1. Breyer MD, Zhang Y, Guan Y, Hao CM, Hebert RL, Breyer RM. Regulation of renal
function by prostaglandin E receptors. Kidney Int. 1998; 54 (suppl. 67):S88-S94
2. Guan Y and Breyer MD. Peroxisome proliferator-activated receptors (PPARs): Novel
therapeutic targets in renal disease. Kidney Int. 2001; 60 (1):14-30.
3. Guan Y, Zhang Y and Breyer MD: The role of PPARs in the transcriptional control of
cellular processes. Drug News & Perspective 2002; 15(3):147-154.
4. Guan Y: Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic
targets for prevention of diabetes, dyslipidemia, hypertension and obesity. Minerva Urologica e Nefrologica 2002; 54:65-79
5. Guan Y: PPAR system and its relationship to renal complications of the metabolic
syndrome. J. Am. Soc. Nephrol. (invited review) 2004 Nov;15(11):2801-15.
6. Guan Y: PPAR-gamma agonists and diabetic nephropathy. Current Diabetes Reports
(in presss) (Invited Review).
BOOK CHAPTERS 1. Targeted gene disruption of the prostaglandin E2 EP2 receptor. In Eicosanoids and
Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. Edited by Honn et al., pp321-326, Kluwer Academic/Plenum Publishers, 2002
2. Vasoactive substances and kidney. in Nephrology . Edited by Haiyan Wang. 2nd ed.
pp 84-180, Public Health Publish House. Beijing. China. 1996
3. Endocrinological Function of Kidney. In Modern Nephrology. Edited by Jije Jiang. 1st
ed. Military Medicine Publish House (in press)
4. Peroxisome proliferator-activated receptors (PPARs) and cardiovascular disease. In
Practical Cardiovascular Receptorology. Edited by Daowen Wang. 1st ed. Science Press, Beijing, ISBN 7-03-009284-8/R.687, 2001, P50-61
5. Scavenger Receptors and cardiovascular disease. In Practical Cardiovascular
Receptorology. Edited by Daowen Wang. 1st ed. Science Press, Beijing, ISBN 7-03-009284-8/R.687, 2001, p62-70
LIST OF PUBLICATIONS 1. Yiang B and Guan Y: Chronic renal failure and recombinant human erythropoietin.
Chinese Journal of Nephrology. 1990. 6:388-391.
2. Guan Y and Qian T: Fibronectin and renal diseases. Advances in Internal Medicine. 1991. 18(5):221-224.
3. Guan Y and Xiu K: Role of reactive oxygen species in gastrointestinal ischemic injury.
Jiangsu Medical Journal 1991. 17(6):322-324.
4. Guan Y, Qian T, and Jiang J: Alteration of the plasma fibronectin concentration in
various kidney disease. Chinese Journal of Nephrology. 1991. 7:81-84.
5. Guan Y, Zhao X, and Jiang J: Significance of hypercoagulable indexes in lupus
nephritis. Tianjin Medical Journal. 1991. 19(6): 349-351.
6. Guan Y, Jiang J, and Qian T: Effect of oral supply of essential amino acids on the
function of kidney and Fc receptor of the peritoneal macrophages in rats with chronic renal failure. Jiangsu Medical Journal. 1991. 17(1):10-12.
7. Zhang, Y, Guan Y, and Jiang J: Structural and functional changes in aged kidneys.
Jiangsu Medical Journal. 1992. 18(1):32-33.
8. Guan Y and Jiang J: Clinical application of recombinant human erythropoietin
(rhuEPO). J. Nephrol. Dialy. Transplant. 1993. 2(1):3-6.
9. Guan Y, Jiang J, Sen Y: Polypeptide growth factors. Advances in Nephrology and Urology. 1993. 13(3):99-103.
10. Guan Y, Wang H: Application of polymerase chain reaction (PCR) technique in
nephrology. Advances in Nephrology and Urology. 1993. 13(4): 162-1655.
11. Guan Y, Jiang J, Qian T: Cyclosporine-associated hypertension. Advances in Internal Medicine. 1993. 20(2):71-73.
12. Guan Y. Decreased expression of c-fos and c-jun oncogenes in aged rat kidneys. Oral
presentation at the First Chinese National Congress of hypertension, fluid, electrolyte metabolism. Apr. 19-21, 1993. Shanghai. China.
13. Guan Y, Xio D and Jiang J: Effect of short-term non-insulin therapy on serum lipid
levels in NIDDM patients. Acta Academia Medicinae Nantong. 1993. 12(4):337-339.
14. Guan Y, Zhang Y, Davis L, Breyer MD: Differential distribution of peroxisome
proliferator-activated receptors (PPARs) along the urinary tract of rabbit and man. Am. J. Physiol. (Renal Physiol.) 1997;273: F1013-F1022.
15. Guan Y, Zhang M, Cho W, Zhang Y, Davis L, Breyer R, Chang, S, DuBois, RN, Hao C,
Breyer MD: Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells. Am. J. Physiol. (Renal Physiol.) 1997; 273: F18-F26
16. Breyer MD, Zhang Y, Guan Y, Hao CM, Hebert RL, Breyer RM. Regulation of renal
function by prostaglandin E receptors. Kidney Int. 1998; 54 (suppl. 67):S88-S94
17. Guan Y, Zhang Y, Breyer R, Fowler, B, Davis L, Hebert, RL, Breyer MD: PGE2
inhibits renal collecting duct Na+ absorption by activating the EP1 receptor. J. Clin. Invest. 1998;102:194-201
18. Hao, C.-M., Komh?ff M, Guan Y, Redha R, Breyer MD: Selective targeting of
cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival. Am. J. Physiol. 1999; 277:F352-F359
19. Kennedy, CRJ, Zhang Y, Brandon S, Guan Y, Coffee K, Funk CD, Magnuson MA,
Oates JA, Breyer MD, Breyer RM: Hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nature Med. 1999; 5:217-220
20. Guan Y, Zhang Y, Davis L, Redha R, Breyer MD: Expression of peroxisome
proliferator-activated receptor ??in human transitional bladder cancer and its role in inducing cell death. Neoplasia 1999; 1(4):330-339.
21. Zhang Y, Guan Y, Schneider A, Brandon S, Breyer RM, Breyer MD: Characterization
of murine vasopressor and vasodepressor prostaglandin E2 receptors. Hypertension 2000, 35; 1129-1134
22. K?mhoff M, Guan Y, Breyer MD: Enhanced expression of cyclooxygenase-2 in high
grade human transitional cell bladder carcinomas. Am. J. Pathol. 2000, 157:29-35.
23. Guan Y and Breyer MD. Peroxisome proliferator-activated receptors (PPARs): Novel
therapeutic targets in renal disease. Kidney Int. 2001; 60 (1):14-30.
24. Shappell SB, Manning S, Boeglin WE, Guan Y, Wheeler TM, Davis L, Jack G, Breyer
MD, Brash AR: Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma. Neoplasia 2001; 3(4): 287-303.
25. Guan Y, Zhang Y, Breyer MD: Peroxisome proliferator-activated receptor gamma
(PPAR?) activity is associated with renal microvasculature. Am. J. Physiol. 2001; 281:F1036-F1046.
26. Guan Y, Zhang Y, Schneider A, Davis L, Breyer MD: cDNA cloning, gene mapping,
and intrarenal localization of mouse prostaglandin E synthase. Am. J. Physiol. 2001; 281:F1173-F1177.
27. Zheng F, Fornoni A, Elliot SJ, Guan Y, Breyer MD, Striker LJ, Striker GE. PPAR?
activation suppresses TGF-? mediated Type I collagen expression in mesangial cells. Am. J. Physiol. (Renal Physiol.) 2002; 282:F639-648
28. Guan Y and Breyer MD: Reply from the authors “Fibrates-induced renal injury”.
Kidney Int. 2002; 61(1):354-355.
29. Jones JR, Shelton KD, Guan Y, Breyer MD, Magnuson MA. Generation and
functional confirmation of a conditional null PPAR? allele in mice. Genesis 2002;
32:134-137.
30. Guan Y, Zhang Y and Breyer MD: The role of PPARs in the transcriptional control of
cellular processes. Drug News & Perspective 2002; 15(3):147-154, Review
31. Panzer U., Scneider A, Guan Y, Reinking R, Zahner G, Harendza S, Wolf G, Thaiss F,
Stahl RAK: Activation of the peroxisome proliferator-activated receptor ? (PPAR?) increases MCP-1 expression and monocyte infiltration in experimental glomerulonephritis. Kidney Int. 2002 Aug;62(2):455-64
32. Guan Y, Stillman B, Breyer R, Zhang Y, Davis L, Redha R, Nian C, Breyer MD:
Cloning and functional expression of the rabbit prostaglandin EP2 receptor. BMC Pharmacology 2002, 2:14 (27 June 2002)
33. Schneider A, Zhang Y, Guan Y, Davis L, Breyer RM, Breyer MD: Differential,
inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice. Am. J. Physiol. (Renal Physiol.) 2003;284:F411-F417.
34. Saito S, Guan Y, Davis L, Breyer M: Expression of the prostaglandin F receptor (FP)
gene along the mouse genitourinary tract. Am. J. Physiol. (Renal Physiol.) 2003; 284:F1164-1170.
35. Peti-Peterdi J, Komlosi P, Bebok Z, Guan Y, Schneider A, Qi Z, Redha R, Breyer M,
Bell PD. Luminal NaCl delivery regulates basolateral PGE2 release from intact Macula densa cells. J. Clin. Invest. 2003 Jul;112(1):76-82
36. Zhang Y, Schneider A, Reena Rao, Wendell J Lu, Fan XF, Davis L, Breyer R, Beryer
MD and Guan Y: Genomic structure and genitourinary expression of mouse cytosolic prosaglandin E2 synthase (cPGES) gene. Biochimica et Biophysica Acta- Mol. Biol. Lipid 2003: 1634; 15-23.
37. Hebert RL, Guan Y, Fowler B, Breyer MD: PGE2 inhibits renal collecting duct
sodium transport and the release of cell calcium by activating the EP1 receptor subtype. Recent Res. Devel. Physiol. 2003; 1:307-317.
38. Schneider A, Zhang Y, Zhang M, Lu W, Rao R, Fan X, Redha R, Davis L, Breyer RM,
Harris R, Breyer MD, Guan Y: Membrane-associated PGES-1 (mPGES-1) is co-expressed with both COX-1 and COX-2 in the kidney. Kidney Int. 2004; 65:1205-1213.
39. Ma L, Ma S-L, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift L.L., Mcguinness
O.P, Wasserman D.H., Fogo A. B. Prevention of obesity and insulin resistance in mice lacking PAI-I gene. Diabetes 2004; 53:336-346.