40. Schneider A, Guan Y, Zhang Y, Magnuson MA, Loftin CD, Langenbach R, Breyer
RM, and Breyer MD: Generation of mice suitable for conditional prostaglandin EP4 receptor deletion. Genesis 2004; 40:7-14
41. Guan Y. Invited Review: PPAR family and renal complications of the metabolic
syndrome. J. Am. Soc. Nephrol. 2004 Nov;15(11):2801-15
42. Zheng F, Chen Q, Plati A-R, Ye S-Q, Berho M, Banerjee A, Potier M, Jaimes EA, Guan
Y, Hao C, Striker LJ, Striker GE. The glomerulosclerosis of aging: Contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration. Am. J. Pathol. 2004; 165:1789-1798;
43. Wu J, Zhang Y, Yang G, Wang N, Zhu Y, Wang X, Davis L, Breyer MD, Guan Y:
Liver X receptor alpha mediates cholesterol efflux in cultured mesangial cells. . Am. J. Physiol. (Renal Physiol.) 2004; 287:F886-F895;
44. Xiong Z, Huang H, LI J, Guan Y, Wang H: Anti-inflammatory effect of PPARg in
cultured human mesangial cells. Renal Failure 2004; 26:497-505;
45. Zeng X-K, Guan Y, Remick D. G. Wang X. Signal pathways underlying
homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Phamacologica Sinica 2005; 26(1):85-91;
46. Wang G, Wei J, Guan Y, Jin N, Mao J, Wang X: PPAR? agonist rosiglitazone reduces
inflammatory response in type II diabetic patients with coronary arterial disease flowing coronary angioplasty. Metabolism 2005; 54(5):590-597.
47. Yang F, Zhang Z, Xin D, Shi C, Wu JP, Guo YL, Guan Y: PPAR? ligands induce cell
cycle arrest and apoptosis in human renal carcinoma cell Lines. Acta Pharmacologica Sinica 2005;26(6):736-761.
48. Guan Y, Hao C, Rao R, Cha DR, Kohan D, Magnuson M, Zhang Y, Breyer MD:
PPAR? regulates systemic fluid volume by activating sodium absorption in the collecting duct._ Nature Medicine 2005 Aug;11(8):861-866;
49. Hebert R, Saito O, Carmosino M, Yang G, Jackson C, Qi Z, Zhang Y, Guan Y, Breyer
M: Characterization of the rabbit PGF2alpha receptor (FP) and its Gi restricted signaling pathway inhibiting water absorption in renal collecting duct. J. Biol. Chem. 280(41):35028-37;
50. Zhan P, Alander C, Kaneko H, Pilbeam CC, Guan Y, Zhang Y, Breyer MD, Raisz LG:
Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: Impaired responsiveness in heterozygous. Prostaglandins Other Lipid Mediat. 2005 Dec;78(1-4):19-26.;
51. Xie L, Chang L, Guan Y, Wang X: C-reactive protein augments interleukin-8
secretion in human peripheral blood monocytes. J Cardiovasc Pharmacol. 2005 Nov;46(5):690-6.
52. Zhang Y & Guan Y: PPAR-gamma agonists and diabetic nephropathy. Current Diabetes Reports 2005；5：470-475 (Invited Review).
53. Park WC, Zhang Y, Wu J, Lu W, Fan X, Davis L, Pozzi A, Capdevila J, Zeng F, Breyer
M, Guan Y: PPARalpha agonist improves diabetic parameters and diabetic nephropathy in db/db mice. Kidney Int. 2006 (in press).
54. Zhang Y, Wu J, Yang G, Lu W, Hwang M-T, Davis L, Breyer M, Guan Y: Liver X
receptor (LXR) agonist TO901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol (Renal Physiol) (in press);
55. Park CW, Kim HW, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y,
Breyer MD: Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome
Proliferator-Activated Receptor-?. Diabetes (in revision);
56. Nakagawa K, Holla VR, Wei Y, Wang W-H, Wei S, Mei S, Cha DR, Price E Jr, Zent
R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman M, Capdevila JH: Salt sensitive hypertension is associated with cytochrome P450 epoxygenase-mediated changes in the activity of the renal epithelial sodium channel. Nature (in revision);
57. Guan Y, Zhang Y, Qi Z, Yang G, Davis L, Wei MF, Fan XF, Breyer R, Breyer MD:
Prostaglandin E2 receptor EP1 is an vasopressor in blood pressure regulation. Cell Metabolism (submitted);
58. Cha DR, Su D., Zhang Y, Fan X, Breyer M, Guan Y: Peroxisome Proliferator
Activated Receptor ? Deficiency Protect From High Fat Diet-Induced Insulin Resistance in Aging Mice. Diabetologia (submitted);
59. Cha DR, Su DM, Han JY, Zhang Y, Fan XF, Breyer MD, Guan Y: PPAR ??? Dual
Agonist Tesaglitazar (AZ242) attenuates Diabetic Nephropathy in db/db Mice. Diabetes (submitted);
60. Zhang Y, Lu W, Fan XF, Shappell SB, Roberts R, Davis L, Guan Y: PPAR? agonists
decrease albuminuria and slow progression of diabetic nephropathy in obese diabetic db/db mice. (in preparation).
61. Zhang Y, Fan XF, Capdevila J, Breyer MD, Guan Y: Activation of a cytochrome p450
arachidonate epoxygenase contributes to normalization of blood pressure produced by the antidiabetic PPAR? ligand troglitazone in SHR rats. (in preparation).
汪南平 教授 博士生导师
专业：生理学
最后学历：医学博士
研究专长：心血管分子生物学与生物工程学 工作单位：北京大学心血管研究所
北京大学医学部生理学与病理生理学系（兼）
联系地址：北京市海淀区学院路38号 北京大学医学部心血管研究所
血管分子生物学与生物工程学研究室 电话：10-82801146
E-mail:npwang@bjmu.edu.cn 学习和工作经历
1983-1986西安医科大学 医学硕士
1986-1988西安医科大学第二临床学院 医师 1989-1990日本北里大学医学部 访问学者 1991-1994北京医科大学 医学博士
1994-1995德国柏林自由大学医学中心 访问学者
1995-1996美国印地安那大学医学院微生物与免疫学系 博士后 1996-2000美国加利福尼亚大学（河滨）生物医学系 博士后
2000-2002美国加利福尼亚大学（河滨）生物医学系 研究助理教授 2003-2005美国加利福尼亚大学（圣地亚哥）生物工程系 研究助理教授 2003- 北京大学医学部心血管研究所 教授 副所长
研究方向代谢性核受体
基因转录调控与功能基因组学 机械-生物信号传导 承担课题
American Heart Association Scientist Development Grant 教育部985专项基金 国家自然科学基金 教育部创新团队基金 主要论文
Eberle,J.; Garbe,C.; Wang,N.; Orfanos,C.E. Incomplete expression of the tyrosinase gene family (tyrosinase, TRP-1, and TRP-2) in human malignant melanoma cells in vitro. Pigment Cell Res. 1995; 8:307-313
Farthmann,B.; Eberle,J.; Krasagakis,K.; Gstottner,M.; Wang,N.; Bisson,S.; Orfanos,C.E. RT-PCR for tyrosinase-mRNA-positive cells in peripheral blood: evaluation strategy and correlation with known prognostic markers in 123 melanoma patients. J.Invest Dermatol. 1998; 110:263-267
Wang, N., Verna, L., Hardy, S., Forsayeth, J., Zhu, Y., Ma, K.S., Stemerman, M.B. Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion
molecule-1 and monocyte chemo-attractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol. 1999; 19:2078-2084
Zhu, Y., Liao, H.L., Wang, N., Friedli, O., Verna, L., Stermerman, M.B. Low-density
lipoprotein activates Jun N-terminal kinase (JNK) in human endothelial cells. Biochimica et Biophisica Acta 1999; 1436:557-64
Wang, N., Verna, L., Hardy, S., Ma, K., Zhu, Y., Birrer, MJ., Stemerman, M.B. c-Jun triggers apoptosis in human vascular endothelial cells. Circ Res. 1999; 85: 387-393
Liao, H.L., Zhu, Y., Wang, N., Verna, L., Stemerman, M.B. Selective activation of endothelial cells by the antioxidant pyrrolidine dithiocarbamate: involvement of c-Jun and Jun N-terminal kinase activation. Endothelium 2000; 7:121-133
Zhu, Y., Liao, H., Wang, N., Yuan, Y., Ma, K., Verna, L., Stemerman, MB. Lipoprotein promotes caveolin-1 and ras translocation to caveolae. Role of cholesterol in endothelial signaling. Arterioscler Thromb Vasc Biol. 2000; 20:2465-2470
Zhu, Y., Liao, H., Wang, N., Ma, K., Verna, L., Shyy, J., Chien, S., Stemerman, MB.
Low-density lipoprotein-activated p38 is mediated by ras. Arterioscler Thromb Vasc Biol. 2001; 21:1159
Wang, N., Verna, L., Zhu, Y., Liao, H., Ballard, A., Stemerman, MB. Adenovirus-mediated overexpression of a dominant negative mutant of c-Jun prevents intercellular adhesion
molecule-1 induction by LDL-A critical role for AP-1 in endothelial activation. Arterioscler Thromb Vasc Biol. 2001; 21: 1414-1420
Yuan, Y., Verna, L., Wang, N., Liao, H., Ma, K., Wang, Y., Zhu, Y., Stemerman, MB. Cholesterol enrichment induces intercellular adhesion molecule-1 in human vascular endothelial cells. Biochimica et Biophisica Acta. 2001; 1534: 139-48
Wang, N., Stemerman, MB. Ref-1 and transcriptional control of endothelial apoptosis. Circ Res 2001; 88:1223 –1225（Editorial）
Wang, N., Verna, L., Chen, N., Chen, J., Li, H, Forman, B.M., Stemerman, MB. Constitutive activation of PPAR-suppresses expression of adhesion molecules in vascular endothelial cells. J Biol Chem 2002; 277: 34176-34181
Wang, N. Cell Adhesion Molecules (CAMs). Encyclopedia of the Neurological Sciences, (Aminoff, MJ., and Daroff, RB, ed) Vol. 1, pp 541-542, Academic Press, San Diego, 2003
Wu J, Zhang Y, Wang N, Davis L, Yang G, Wang X, Zhu Y, Breyer MD, Guan Y. Liver X receptor alpha (LXRalpha) mediates cholesterol efflux in glomerular mesangial cells. Am J Physiol Renal Physiol. 2004; 287:F886-895
Liu,Y., Zhu, Y., Rannou, F., Lee, T-S., Formentin, K., Zeng, L., Yuan, X., Wang, N., Chien, S., Forman, B.,Shyy, Y-J. Laminar flow activates peroxisome proliferator-activated receptor-in vascular endothelial cells. Circulation 2004; 28-1133
Yan H, Guo Y, Zhang P, Zu L, Dong X, Chen L, Tian J, Fan X, Wang N, Wu X,Gao W. Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors. Biochem Biophys Res Commun. 2005; 26:336:287-298
Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005; 68:425-32
张鹏, 汪南平. 脂肪因子与代谢综合征.基础医学与临床, 2006, 26:20-26.
Wu, C, Li ,Y ,. Haga, J, Wang,N, Lian, I, Su, F, Usami, S and S Chien. Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow. J Cell Biochem. 2006 Jan 26; [Epub ahead of print]
Wang,N.; Miao,H.; Li,Y.S.; Zhang,P.; Haga,J.H.; Hu,Y.; Young,A.; Yuan,S.; Nguyen,P.; Wu,C.C.; Chien,S. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006; 341:1244-1251
Wu,X.; Ma,J.; Han,J.D.; Wang,N.; Chen,Y.G. Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors. Microvasc.Res.2006; 71:12-9