总之，本文通过比较各组中MMPs及TIMPs的mRNA表达水平显示，虽然在有恶变倾向的葡萄胎中的表达均略高于良性葡萄胎和正常绒毛，但差异无显著性；而MMP?9/TIMP?1比值在葡萄胎恶变组中的表达高于正常绒毛组和葡萄胎未恶变组,因此认为MMP?9/TIMP?1比值可望作为判断葡萄胎预后的一项参考指标，特别是对葡萄胎有恶变倾向的病人进行预防性化疗可提供理论依据。
【参考文献】
[1]宋鸿钊. 滋养细胞肿瘤的诊断和治疗[J].北京：人民卫生出版社, 2004：88?92.
[2]乐杰. 妇产科学[M]. 第6版.北京：人民卫生出版社, 2003:319?329.
[3]娄艳辉,钱金花,郭新华. MMP?1及TIMP?1在异位内膜组织中的表达[J]. 齐鲁医学杂志， 2004,19(5):392?393.
[4]LIU X P, KAWAUCHI S, OGA A, et al. Prognostic significance of matrix metalloproteinase?7 (MMP?7) expression at the invasive front in gastric carcinoma[J]. Cancer Research, 2002,93(3):291?295.
[5]TANIOKA Y, YOSHIDA T, YAGAWA T, et al. Matrix metalloproteinase?7 and matrix metalloproteinase?9 are associated with unfavorable prognosis in superficial oesophageal cancer[J]. Br J Cancer, 2003,89(11):2116?2121.
[6]MISUGI F, SUMI T, OKAMOTO E, et al. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase?7 and prognosis[J]. Int J Mol Med, 2005,16（4）：541?546.