肿瘤,一个发育生物学问题 - 生命科学(5)

2020-11-27 10:55

第5期马 芳,等:肿瘤,一个发育生物学问题437

激淋巴细胞增殖和抑制肿瘤细胞生长。有人将白血病细胞注入小鼠胚胎的胎盘得到了具有嵌合的造血系统的正常小鼠。

3 结 语

尽管我们已经步入了生命科学时代,然而我们对生命的探索是远远不够的。恶性肿瘤是一种特殊的疾病,与我们的健康和生命休戚相关,人们期望利用新的科学思维方法来重新理解恶性肿瘤的发病机理及其生物学行为,也渴望找到生命的真正含义。我们相信从发育生物学的视角来思考肿瘤和研究肿瘤,无论对个体发育的探索,还是对恶性肿瘤的认知都会有更深入的认识和收获。

从发育生物学的角度认识肿瘤,以及对胚胎与肿瘤相互作用的进一步研究有利于我们深入地理解胚胎和肿瘤两种“正-邪”生命现象的内涵,拓展和补充“肿瘤的胚胎源性”概念。同时也有助于人们从生命现象中去寻求认识肿瘤、征服肿瘤的新“曙光”。这个交叉领域的研究对于解析生命现象本身也提供了新的思维方法和探索方向,为肿瘤细胞的分化和表型研究提供了实验理论和技术平台。

[参 考 文 献]

[1]

Kelly T L,Trasler J M. Reproductive epigenetics.Clin Genet,

2004, 65 (4): 247~260

[2]Papaioannou V E. Ontogeny, pathology, oncology. Int J Dev

Biol, 1993, 37(1): 33~37

[3]Hanahan D, Weinberg R A. The hallmark of cancer. Cell,

2000, 100(1): 57~70

[4]Reya T, Morrison S J, Clarke M F, et al. Stem cells, cancer,

and cancer stem cells. Nature, 2001, 414(6859): 105~111[5]Wilmut I, Schnieke A E, Kind A J, et al. Viable offspring

derived from fetal and adult mammalian cells. Nature, 1997,386(6619): 810~813

[6]Gao S, Latham K E. Maternal and environmental factors in

early cloned embryo development. Cytogenet Genome Res,2004, 105 (2-4): 279~284

[7]Crowe D L, Parsa B, Sinha U K. Relationships between

stem cells and cancer stem cells. Histopathol, 2004, 19(2):505~509

[8]Danet G H, Lee H W, Luongo J L, et al. Dissociation be-tween stem cell phenotype and NOD/SCID repopulatingactivity in human peripheral blood CD34(+) cells after ex vivoexpansion. Exp Hematol, 2001, 29(12): 1465~1473

[9]Grimwade D, Enver T. Acute promyelocytic leukemia: where

does it stem from? Leukemia, 2004, 18 (3): 375~384

[10]Bonnet D,Dick J E.Human acute myeloidleukemia is

organized as a hierarchy that originates from a primitivehematopoietic cell.Nat Med, 1997, 3: 730~737.

[11] Wicha M S, Dontu G, Al-Hajj M, et al. Stem cells in normal

breast development and breast cancer. Cell Prolif, 2003, 36(Suppl 1): 59~72

[12]

Singh S K, Clarke I D,Terasaki M, et al. Identification of acancer stem cell in human brain tumors. Cancer Res, 2003, 63(18): 5821~5828

[13]Singh S K, Clarke I D, Hide T, et al. Cancer stem cells innervous system tumors. Oncogene, 2004, 23(43): 7267~7273[14]Nakano I, Hemmati H D, Kornblum H I. Cancer stem cell inpediatric brain tumor. No Shinkei Geka, 2004, 32(8): 827~834[15]Al-Hajj M, Clarke MF. Self-renewal and solid tumor stemcells. Oncogene, 2004, 23(43): 7274~7282

[16]Sell S. Stem cell origin of cancer and differentiation therapy.Crit Rev Oncol Hemato, 2004, 51 (1): 1~28

[17]Murray M J, Lessey B A.Embryo implantation and tumormetastasis: common pathways of invasion and angiogensis.Semin Reprod Endocrinol, 1999, 17(3): 275~290

[18]

VogelsteinB,Kinzler K W.Cacer genes and the pathways theycontrol. Nat Med, 2004, 10(8): 789~799

[19]Petruzzelli G J. The biology of tumor invasion, angiogenesisand lymph node metastasis. ORL, 2000, 62(4): 178~185[20]Rinkenberger J L, Horning S, Klocke B, et al. Mcl-1defi-ciency results in prei-implantation embryonic lethality.Genes Dev, 2000, 14(1): 23~27

[21]Okano M, Li E. Genetic analyses of DNA methyltransferasegenes in mouse model system. J Nutr, 2002, 132: 2462S~2465S[22]

Soejima K, Fang W, Rollins B J. DNA methyltransferase 3bcontributes to oncogenic transformation induced by SV40Tantigen and activated Ras. Oncogene, 2003, 22(30):4723~4733

[23]Winston N. Regulation of early embryo development: func-tional redundancy between cyclin subtypes. Reprod FertilDev, 2001, 13(1): 59~67

[24]

Heikinheimo O, Gibbons W E. The molecular mechanismsof oocyte maturation and early embryonic development areunveiling new insights into reproductive medicine. Mol HumReprod, 1998, 4(8): 745~756

[25]Levy R. Genetic regulation of preimplantation embryosurvival. Int Rev cytol, 2001, 210: 1~37

[26]

Wrenzycki C, Niemann H. Epigenetic reprogramming in earlyembryonic development: effects of in vitro production andsomatic nuclear transfer. Reprod Biomed Online, 2003, 7 (6):649~656

[27]

Brinster R L. The effect of cells transferred into the mouseblastocyst on subsequent development. J Exp Med, 1974, 140(4): 1049~1056

[28]

Papaioannou V E, Waters B K, Rossant J. Interactions be-tween diploid embryonal carcinoma cells and early embry-onic cells. Cell Differ, 1984, 15(2-4): 175~179

[29]

Hanaoka K, Hayasaka M, Noguchi T, et al. The stem cells ofa primordial germ cell-derived teratocarcinoma have theability to form viable mouse chimeras. Differentiation, 1991,48(2): 83~87

[30]

Hartmut G, Stefanie S, Constanze B T, et al. Globin geneexpression is reprogrammed in chimeras generated by inject-ing adult hematopoietic stem cells into mouse blatocysts.Cell, 1998, 93: 1055~1065

[31]

Harder F, Henschler R, Junghahn I, et al. Human hemato-poiesis in murine embryos after injecting human cord blood-


肿瘤,一个发育生物学问题 - 生命科学(5).doc 将本文的Word文档下载到电脑 下载失败或者文档不完整,请联系客服人员解决!

下一篇:2015-2020年中国生物原杀虫剂市场调研及投资战略研究报告

相关阅读
本类排行
× 注册会员免费下载(下载后可以自由复制和排版)

马上注册会员

注:下载文档有可能“只有目录或者内容不全”等情况,请下载之前注意辨别,如果您已付费且无法下载或内容有问题,请联系我们协助你处理。
微信: QQ: