尽管免疫导向金纳米粒子在癌症成像与治疗中的最初尝试性应用获得了成功,这种方法依然有很多因素需要进一步的优化。优化的主要方面有纳米粒子吸收和散射的截面,靶项抗体同纳米粒子的结合,以及纳米粒子生物复合的靶位点。尽管很多研究都是针对单层细胞展开,但是在实际应用中还需要对纳米粒子药物代谢动力学上的研究,包括血流量,渗透行为,肿瘤扩散,生理反应,纳米粒子的稳定性,等等[120-123]。并且,还有必要研究这些因素对纳米粒子的尺寸,表面化学作用,以及传输模式的依赖性。还有,将近红外光施加到不同癌症的感染细胞上的最有效方法也需要进一步的研究。纳米粒子辅助光热调制装置对细胞的损害也并没有完全的解释,依然需要进一步的研究。在所有这些方面的系统研究是等离子体纳米粒子在癌症探测和选择性光热调制治疗医用设备中的成功应用的前提条件。
12.总结
近年来,LSPR技术由于其独特的性质得到了广泛的关注和研究。这篇论文综述了LSPR技术的发展状况并且讨论了以此技术为基础的传感器的应用和测试。总体说来,通过LSPR传感器在各领域如物理,化学,生物方面对于小量分子或高灵敏度物质的探测,我们可以得知LSPR技术具有相当大的潜力。同时,通过LSPR为基础的器件的研究和开发,以及在实验方面所尝试的应用实例的介绍,我们可以想象,LSPR技术以及基于LSPR的生物传感器技术将会极大地促进相关领域的监测学和诊断学的发展。由于基于LSPR技术的各类传感器和传感芯片所需配合仪器便于携带,操作简单,成本低廉,而灵敏度却很高,可以预见的是,这种传感技术将会具有相当可观的商业前景,而对于其的后续研究和改进完善工作也是十分必要的。对于LSPR技术及其相关传感技术的研究存在着深远的意义。
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