学校代码： 10128 学 号： 200820515031
本科毕业设计说明书
（
题 目：800 t/a土霉素生产车间脱色结晶（间
歇）干燥工段工艺设计
学生姓名：赵 东 辉 学 院：化工学院 系 别：化学工程系 专 业：制药工程
班 级：制药工程08-1班 指导教师：竺宁 讲师
二 零 一 二 年 六 月
内蒙古工业大学本科毕业设计说明书
摘 要
土霉素生产过程包括发酵、酸化、过滤、脱色、结晶、干燥几个主要工段。本次设计为800 t/a土霉素生产车间脱色、结晶（间歇）、干燥工段的设计。对土霉素的生产工艺过程进行了物料衡算和热量衡算，进而进行了设备选型，最终绘制了物料流程图，工艺管道及仪表流程图，设备的平、立面布置。发酵工段需要一级发酵、二级发酵和三级发酵得到发酵液，然后经过盐酸的酸化后再经过板框过滤机过滤进行脱色、结晶、干燥制成成品。本次设计任务的主要工段是脱色、结晶和干燥。脱色装置采用大孔交换树脂进行三组3罐脱色；结晶过程可采用间歇和连续结晶两种，结晶关系到产品的分离和提纯，本次设计选择间歇结晶的方法。结晶后将结晶液通入离心机中进行离心处理，最后将离心处理后所得的湿物料通入到干燥车间进行干燥，生产出合格的产品。
关键词：土霉素；脱色；结晶；干燥
内蒙古工业大学本科毕业设计说明书
Abstract
The several major public paragraphs including fermentation, acidification, filters, discoloring, the crystallization and dry in oxytetracycline production process. This design is that the public paragraph of discoloring and crystallization of oxytetracycline production workshop of 350t/a. Doing material accountancy and heat balance and for the production process of oxytetracycline. We determine the site selection and equipment selection and so on by calculating. Finally we draw the material flow chart, process piping and flow chart meters, equipment list and the level, facade layout of the workshop equipment.After the first fermentation, secondary fermentation and third fermentation develop cracks fermentation liquor, then after the acidification hydrochloric acid it is filter into the frame, and decolorization conducted, crystal, dry and the finally manufacturing the finished products. The main section is decolorization and crystallization in this design. Used the decolorization devices of large-exchange resins to group 3 . There are two kind of crystal ways, the first one is crystal intermittent and the second one is continuous crystallization. Crystallization related to separation and purification of products, we used the continuous crystallization in this design. Put the liquid crystal centrifugalde into the centrifuge after the crystal. Finally we will obtain the wet materials after centrifugalde dryde into the drying workshop, and finally we product the qualified products.
Keywords: oxytetracycline, decoloring, crystallization
内蒙古工业大学本科毕业设计说明书
目 录
引 言 ................................................................. 1 第一章 产品概述 ........................................................ 2
1.1产品名称、结构及性质 ............................................ 2 1.2药理作用 ........................................................ 2 1.3主要用途 ........................................................ 3 第二章 土霉素生产工艺流程 .............................................. 4
2.1设计依据 ........................................................ 4 2.2设计的指导思想和设计基本原则 .................................... 4
2.2.1指导思想 ................................................... 4 2.2.2基本原则 ................................................... 4 2.3工艺流程图 ...................................................... 4 2.4土霉素主要工艺流程及要求 ........................................ 5
2.4.1土霉素发酵工段 ............................................. 5 2.4.2提炼工段 ...................................................... 6 2.4.3脱色、结晶、干燥工段 .......................................... 6 第三章 物料衡算 ........................................................ 7
3.1 物料衡算依据 .................................................... 7 3.2发酵工段 ........................................................ 7
3.2.1一级种子培养 ............................................... 7 3.2.2二级种子培养 ............................................... 8 3.2.3三级发酵 ................................................... 9 3.3酸化工段 ....................................................... 11 3.4过滤工段 ....................................................... 12 3.5脱色工段 ....................................................... 14 3.6结晶工段 ....................................................... 15 3.7干燥工段 ....................................................... 17 第四章 热量衡算 ....................................................... 18
4.1热量衡算的目的 ................................................. 18 4.2热量衡算的依据及必要条件 ....................................... 19
内蒙古工业大学本科毕业设计说明书
4.3热量衡算主要的计算公式 ......................................... 19
4.3.1设备的热量平衡方程式 ...................................... 19 4.3.2比热容的计算 .............................................. 20 4.3.3化合物比热容 .............................................. 21 4.3.4其它各温度下化合物的比热容 ................................ 21 4.4基本数据的计算 ................................................. 22 4.5热量计算 ....................................................... 24
4.5.1一级种子罐 ................................................ 24 4.5.2二级种子罐 ................................................ 28 4.5.3三级发酵罐 ................................................ 32 4.5.4补料罐 .................................................... 35 4.5.5干燥工段 .................................................. 39
第五章 设备选型及计算 ................................................. 41
5.1 发酵罐的选型 .................................................. 41
5.1.1一级种子罐的选型 .......................................... 41 5.1.2 二级种子罐的选型 ........................................ 42 5.1.3 三级种子罐的选型 ........................................ 43 5.2补料罐的选型 ................................................... 46 5.3 酸化罐的选型 ................................................... 48 5.4 树脂罐的选型 ................................................... 49 5.5 结晶罐的选型 ................................................... 50 6.6离心机的选型 ................................................... 50 5.6干燥器的选型 ................................................... 51 第 6 章 车间布置设计 ................................................ 57
6.1车间布置概述 ................................................... 57 6.2车间组成 ....................................................... 57 6.3车间区域和工艺设备布置原则 ..................................... 57 6.4厂房平面布置 ................................................... 57 6.4厂房垂直布置 ................................................... 57 第七章 三废处理 ....................................................... 58
7.1三废的概述 ..................................................... 58