法仍是研究人员努力的方向。HPLC法在有关物质分析中仍将占主导地位，TLC法和GC法则是补充手段。随着技术、方法的成熟，CE法也有望成为一种常规分析手段，特别是在手性异构体的检查中能发挥重要的作用。近几年SFC、UPLC、CEC等方法在有关物质研究中的应用逐年增加，但其重复性还有待进一步改善。在有关物质的结构分析中，LC-MS及LC-MS-MS技术已相当成熟。近年来，LC-NMR技术有了较大的发展，凭借着强大的结构鉴定能力，其在有关物质的结构分析中必将有着较好的应用前景。随着检测手段的进一步完善，人们对药物中有关物质的研究将会更加深入，药品质量也将得到进一步的提升。
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