钯催化的插羰反应(5)

经典合成反应标准操作—钯催化的插羰反应

I+CO+CO2EtCO2EtPd(0), dppfEt3N, 120oC, 75%OCO2EtCO2Et8-1

Iodobenzene (1.8 mmol) and diethyl methylmalonate (2.0 mmol) in triethyl amine (2 mL) were reacted with carbon monoxide (20 atm) at 120℃ in the presence of a catalytic amount of dichloro[1,1’-bis(diphenylphosphino)ferrocene]-palladium (1.88*10-2mmol). GLC analysis of the resulting mixture revealed the formation of diethyl methylbenzoylalonate in 75.3% yield. The mixture was filtered and distilled (Kugelrohr) to give the pure sample (61% isolated yield).

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