综述
虑原料的价格、设备、反应条件、反应对环境的影响等诸多因素显得尤为重要。
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参考文献
参考文献
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[4] Owens D R. Repaglinide prandial glueose regulator a new class of oral antidiabetic drugs[J].Diabet Med. 1998.15(suppl 4):28.
[5] John R, White J R, Pharm D. The pharmacological reduction of blood glucose in patients with type 2 diabetes mellitus[J].Clin Diabetes, 1998, 16: 2.
[6] Fuhlendorff J. Rorsman P. Kofod H, et a1.Stimulation 0f insulin release by repaglinide and glibenelamide involvesboth common and distict processes[J]. Diabetes, 1998, 47: 345.
[7] 刘莉, 王修乾.格林美脲与诺合龙治疗初发Ⅱ型糖尿病的疗效比较[J].中国误诊学杂志, 2005, 5(17): 3316.
[8] 焦凯.餐食胰岛素促泌剂瑞格列奈作用特点与临床应用[J].实用糖尿病杂志,2005, 1(3): 60.
[9] Damsbo P, Clauson P, Marbury T C. et al. A double blind randomited comparison of meal-related glyeemic control by repaglinide and glyburide in well-controlled type 2 diabetic patients[J].Diabetes care. 1999, 22(5): 789.
[10] 郑良玉, 王恩思, 俞加林. 外消旋瑞格列奈的合成[J]. 吉林大学自然科学学报, 2000, 3(4): 83-87.
[11] 杨健,许惠钢.一种合成瑞格列奈的工艺[P].CN200610052067[P].2006-11-22. [12] Salman M. Babu S.An Efficient and Cost-effective Synthesis of 3-ethoxy-4- Ethoxycarbonyl- phenylacetic Acid: A Key Acid Synthon of Repaglinide[J].Organic Process Research＆ Development, 2002, 6(3): 184-186.
[13] Kolla N,Elati K, Sajja E, et a1.An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1(2-piperidin-1-ylpheny1)butan-1- amine: A Useful Intermediate [J].Process Chemistry.2006, 60(9): 594-597.
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参考文献
[14] 钟慧娟. 一种制备瑞格列奈的方法[P]. CN200710103833[P]. 2007-10-10. [15] 陈万锁,陈志荣.(S)-3-甲基-1-[2-(1-哌啶基)苯基]丁胺的合成[P].CN 200410110505[P]. 2004-12-27..
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附录
化 合 物 图 谱
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附录
瑞格列奈中间体H-NMR
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瑞格列奈中间体H-NMR低场区局部放大图
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附录
瑞格列奈H-NMR
1
瑞格列奈H-NMR低场区局部放大图
1
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